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Literature summary for 3.4.24.22 extracted from

  • McMahan, R.S.; Birkland, T.P.; Smigiel, K.S.; Vandivort, T.C.; Rohani, M.G.; Manicone, A.M.; McGuire, J.K.; Gharib, S.A.; Parks, W.C.
    Stromelysin-2 (MMP10) moderates inflammation by controlling macrophage activation (2016), J. Immunol., 197, 899-909 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.22

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
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 Mus musculus
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-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ zinc metalloproteinase Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus O55123
-
-
Mus musculus C57BL/6J O55123
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-

Source Tissue

Source Tissue Comment Organism Textmining
bronchoalveolar lavage fluid
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 Mus musculus
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macrophage isolated resident alveolar and bone marrow-derived macrophages (BMDM) Mus musculus
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additional information MMP10 (stromelysin-2) is not expressed in developing or normal adult tissues, including lung Mus musculus
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Synonyms

Synonyms Comment Organism
MMP10
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 Mus musculus
stromelysin-2
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 Mus musculus

General Information

General Information Comment Organism
malfunction in acute Pseudomonas aeruginosa infection, 50% of Mmp10-/- mice die and all show sustained weight loss (morbidity), but lethality and morbidity in Mmp10-/- mice are not due to impaired bacterial clearance. Mmp10-/- mice die due to altered or excessive inflammation Mus musculus
metabolism macrophage MMP10 promotes the ability of M2 macrophages to clear scar tissues in normal skin wounds by controlling the expression of collagenolytic MMPs, particularly MMP13 Mus musculus
physiological function MMP10 regulates macrophage activation. macrophage MMP10 serves a beneficial function in response to acute Pseudomonas aeruginosa infection. Whereas wild-type mice survive infection with minimal morbidity, while 50% of Mmp10-/- mice die and all show sustained weight loss (morbidity). MMP10 serves a beneficial role in response to acute infection by moderating the pro-inflammatory response of resident and infiltrating macrophages. MMP10 serves a protective role in acute infection by moderating the pro-inflammatory activity of macrophages Mus musculus